MovDisordV3, Main, Exploration, bibRecord, 000E29

Cumulative exposure to lead and cognition in persons with Parkinson’s disease

Identifieur interne : 000E29 ( Main/Exploration ); précédent : 000E28; suivant : 000E30

Cumulative exposure to lead and cognition in persons with Parkinson’s disease

Auteurs : Jennifer Weuve [États-Unis] ; Daniel Z. Press [États-Unis] ; Francine Grodstein [États-Unis] ; Robert O. Wright [États-Unis] ; Howard Hu [États-Unis] ; Marc G. Weisskopf [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2012.

RBID : PMC:3581753

English descriptors

KwdEn :
- Age of Onset, Aged, Aged, 80 and over, Bone and Bones (chemistry), Cognition (physiology), Educational Status, Environmental Exposure, Female, Humans, Lead (analysis), Lead Poisoning, Nervous System (complications), Lead Poisoning, Nervous System (psychology), Learning (physiology), Male, Memory (physiology), Middle Aged, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (psychology), Reproducibility of Results, Smoking (epidemiology), Spectrometry, X-Ray Emission, Telephone, Trail Making Test, Verbal Behavior (physiology).
MESH :
- chemical , analysis : Lead.
- chemistry : Bone and Bones.
- complications : Lead Poisoning, Nervous System, Parkinson Disease.
- epidemiology : Smoking.
- physiology : Cognition, Learning, Memory, Verbal Behavior.
- psychology : Lead Poisoning, Nervous System, Parkinson Disease.
- Age of Onset, Aged, Aged, 80 and over, Educational Status, Environmental Exposure, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Reproducibility of Results, Spectrometry, X-Ray Emission, Telephone, Trail Making Test.

Abstract

Background

Dementia is an important consequence of Parkinson’s disease (PD), with few known modifiable risk factors. Cumulative exposure to lead, at levels experienced in the community, may exacerbate PD-related neural dysfunction, resulting in impaired cognition.

Methods

Among 101 persons with PD (“cases”) and, separately, 50 persons without PD (“controls”), we evaluated cumulative lead exposure, gauged via tibia and patella bone lead concentrations, in relation to cognitive function, assessed using a telephone battery developed and validated in a separate sample of PD patients. We also assessed the interaction between lead and case-control status.

Results

After multivariable adjustment, higher tibia bone lead concentration among PD cases was associated with worse performance on all of the individual telephone tests. In particular, tibia lead levels corresponded to significantly worse performance on a telephone analogue of the Mini-Mental State Examination and tests of working memory and attention. Moreover, higher tibia bone lead concentration was associated with significantly worse global composite score encompassing all the cognitive tests (P=0.04). The magnitude of association per standard deviation increment in tibia bone lead level was equivalent to the difference in global scores among controls in our study who were about seven years apart in age. The tibia lead-cognition association was notably stronger within cases than within controls (P_difference=0.06). Patella bone lead concentration was not consistently associated with performance on the tests.

Conclusions

These data provide evidence suggesting that cumulative exposure to lead may result in worsened cognition among persons with PD.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581753

DOI: 10.1002/mds.25247
PubMed: 23143985
PubMed Central: 3581753

Affiliations:

Le document en format XML

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<author><name sortKey="Weisskopf, Marc G" sort="Weisskopf, Marc G" uniqKey="Weisskopf M" first="Marc G." last="Weisskopf">Marc G. Weisskopf</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of Onset</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Bone and Bones (chemistry)</term>
<term>Cognition (physiology)</term>
<term>Educational Status</term>
<term>Environmental Exposure</term>
<term>Female</term>
<term>Humans</term>
<term>Lead (analysis)</term>
<term>Lead Poisoning, Nervous System (complications)</term>
<term>Lead Poisoning, Nervous System (psychology)</term>
<term>Learning (physiology)</term>
<term>Male</term>
<term>Memory (physiology)</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (psychology)</term>
<term>Reproducibility of Results</term>
<term>Smoking (epidemiology)</term>
<term>Spectrometry, X-Ray Emission</term>
<term>Telephone</term>
<term>Trail Making Test</term>
<term>Verbal Behavior (physiology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Lead</term>
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<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Bone and Bones</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Lead Poisoning, Nervous System</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Smoking</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cognition</term>
<term>Learning</term>
<term>Memory</term>
<term>Verbal Behavior</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Lead Poisoning, Nervous System</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Age of Onset</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Educational Status</term>
<term>Environmental Exposure</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Reproducibility of Results</term>
<term>Spectrometry, X-Ray Emission</term>
<term>Telephone</term>
<term>Trail Making Test</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Dementia is an important consequence of Parkinson’s disease (PD), with few known modifiable risk factors. Cumulative exposure to lead, at levels experienced in the community, may exacerbate PD-related neural dysfunction, resulting in impaired cognition.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Among 101 persons with PD (“cases”) and, separately, 50 persons without PD (“controls”), we evaluated cumulative lead exposure, gauged via tibia and patella bone lead concentrations, in relation to cognitive function, assessed using a telephone battery developed and validated in a separate sample of PD patients. We also assessed the interaction between lead and case-control status.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">After multivariable adjustment, higher tibia bone lead concentration among PD cases was associated with worse performance on all of the individual telephone tests. In particular, tibia lead levels corresponded to significantly worse performance on a telephone analogue of the Mini-Mental State Examination and tests of working memory and attention. Moreover, higher tibia bone lead concentration was associated with significantly worse global composite score encompassing all the cognitive tests (<italic>P</italic>
=0.04). The magnitude of association per standard deviation increment in tibia bone lead level was equivalent to the difference in global scores among controls in our study who were about seven years apart in age. The tibia lead-cognition association was notably stronger within cases than within controls (<italic>P<sub>difference</sub>
</italic>
=0.06). Patella bone lead concentration was not consistently associated with performance on the tests.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">These data provide evidence suggesting that cumulative exposure to lead may result in worsened cognition among persons with PD.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Illinois</li>
<li>Massachusetts</li>
<li>Michigan</li>
</region>
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<tree><country name="États-Unis"><region name="Illinois"><name sortKey="Weuve, Jennifer" sort="Weuve, Jennifer" uniqKey="Weuve J" first="Jennifer" last="Weuve">Jennifer Weuve</name>
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<name sortKey="Grodstein, Francine" sort="Grodstein, Francine" uniqKey="Grodstein F" first="Francine" last="Grodstein">Francine Grodstein</name>
<name sortKey="Grodstein, Francine" sort="Grodstein, Francine" uniqKey="Grodstein F" first="Francine" last="Grodstein">Francine Grodstein</name>
<name sortKey="Hu, Howard" sort="Hu, Howard" uniqKey="Hu H" first="Howard" last="Hu">Howard Hu</name>
<name sortKey="Press, Daniel Z" sort="Press, Daniel Z" uniqKey="Press D" first="Daniel Z." last="Press">Daniel Z. Press</name>
<name sortKey="Weisskopf, Marc G" sort="Weisskopf, Marc G" uniqKey="Weisskopf M" first="Marc G." last="Weisskopf">Marc G. Weisskopf</name>
<name sortKey="Weisskopf, Marc G" sort="Weisskopf, Marc G" uniqKey="Weisskopf M" first="Marc G." last="Weisskopf">Marc G. Weisskopf</name>
<name sortKey="Weuve, Jennifer" sort="Weuve, Jennifer" uniqKey="Weuve J" first="Jennifer" last="Weuve">Jennifer Weuve</name>
<name sortKey="Wright, Robert O" sort="Wright, Robert O" uniqKey="Wright R" first="Robert O." last="Wright">Robert O. Wright</name>
<name sortKey="Wright, Robert O" sort="Wright, Robert O" uniqKey="Wright R" first="Robert O." last="Wright">Robert O. Wright</name>
<name sortKey="Wright, Robert O" sort="Wright, Robert O" uniqKey="Wright R" first="Robert O." last="Wright">Robert O. Wright</name>
</country>
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Movement Disorders (revue)

Cumulative exposure to lead and cognition in persons with Parkinson’s disease

Cumulative exposure to lead and cognition in persons with Parkinson’s disease

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English descriptors

Abstract

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	Movement Disorders (revue)
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